Note to self: Know where your configuration files are.
I have been fighting an APC out of memory/100% fragmentation nightmare. I kept tweeking settings in /etc/php.ini and nothing seemed to be fixing the problem. Sure, gracefully restarting Apache will appear to fix the issue at the moment, but then it returned.
I started looking at the Runtime settings in apc.php and realized that nothing I had set really changed anything. Turns out, apc by default put its config in /etc/php.d/apc.ini. Sure, I would set them in php.ini and then they were overwritten in apc.ini. ARGH!!!!
Found and fixed… YAY!